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While this challenge is inherent to all Fc-containing ADCs, the dual-targeting nature of BsADCs necessitates particularly careful optimization of Fc function to balance potential efficacy (e.g., ADCC) against the risk of off-target toxicity

Musculoskeletal: Joint pain (arthralgia), muscle aches and mild peripheral edema

Passing the baton: The HIF switch

These transporters co-transport Na and Cl along with their substrates, a mechanism common in neurotransmitter transporters (Raiteri and Raiteri 2010

For calculations of prepost change in telomerase and telomere length showing statistical significance, change in the proportion of lymphocytes to monocytes was added as a nuisance variable 56